New generation of painkillers is possible
University of Manchester researchers said their finding could lead to the next generation of analgesics designed for such chronic conditions as migraines and backache.
The scientists examined microscopic amoeboid organisms commonly called slime moulds in a bid to gain greater insight into pain molecules known as ‘P2X receptors’.
“In humans, P2X receptors look identical to one another and so scientists have had difficulty understanding how they function,” said Chris Thompson, who carried out the research with Professor Alan North and Sam Fountain.
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Thompson and colleagues discovered there was only a 10 percent similarity between human P2X and the slime mould equivalent. They were therefore able to deduce from evolutionary theory that it was these similar parts of the molecule that probably regulate pain in humans.
“Inhibiting P2X as a potential pain-relief therapy would be the Holy Grail of rational drug design and could revolutionize the way we manage chronic pain conditions like back pain and migraine,” said Thompson.
The research is detailed in the journal Nature.
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